OTC : CALA
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| Filing Date | Reporting Person | Amount Beneficially Owned | % of Class |
|---|---|---|---|
| 2022-04-21 | Takeda Pharmaceutical Company Limited | 14.82M | 13.20% |
| 2022-04-21 | Millennium Pharmaceuticals, Inc. | 14.82M | 13.20% |
| 2022-04-11 | 2. | 10.0 | 0.00% |
| 2022-04-11 | 2. | 10.0 | 0.00% |
| 2022-04-11 | 2. | 10.0 | 0.00% |
| 2022-04-11 | 2. | 10.0 | 5.30% |
| 2022-04-11 | 2. | 10.0 | 5.30% |
| 2022-04-11 | 2. | 10.0 | 5.40% |
| 2022-04-11 | 2. | 10.0 | 5.30% |
| 2022-04-11 | 2. | 10.0 | 0.00% |
| 2022-04-11 | 2. | 10.0 | 5.30% |
| 2022-04-11 | 2. | 10.0 | 5.30% |
| 2022-04-11 | 2. | 10.0 | 5.30% |
| 2022-04-11 | 2. | 10.0 | 0.00% |
| 2022-04-11 | 2. | 10.0 | 0.00% |
| 2022-04-11 | 2. | 10.0 | 5.40% |
| 2022-02-14 | 2. | 10.0 | 4.70% |
| 2022-02-14 | 2. | 10.0 | 4.80% |
| 2022-02-14 | 2. | 10.0 | 0.20% |
| 2022-02-14 | 2. | 10.0 | 0.20% |
| 2022-02-14 | 2. | 10.0 | 0.20% |
| 2022-02-14 | 2. | 10.0 | 4.70% |
| 2022-02-14 | 2. | 10.0 | 4.70% |
| 2022-02-10 | Phillip Gross | - | 0.00% |
| 2022-02-10 | Adage Capital Partners GP, L.L.C. | - | 0.00% |
| 2022-02-10 | PRIMECAP Management Company | 10.73M | 14.32% |
| 2022-02-10 | PRIMECAP Management Company | 10.73M | 14.32% |
| 2022-02-10 | Adage Capital Partners, L.P. | - | 0.00% |
| 2022-02-10 | Adage Capital Advisors, L.L.C. | - | 0.00% |
| 2022-02-10 | Robert Atchinson | - | 0.00% |
| 2021-12-10 | Voting Shares Irrevocable Trust | 1418.0 | 0.00% |
| 2021-12-10 | Rhodora J. Donahue | 1418.0 | 0.00% |
| 2021-12-10 | J. Christopher Donahue | 1418.0 | 0.00% |
| 2021-12-10 | Federated Hermes, Inc. | 1418.0 | 0.00% |
| 2021-12-10 | Thomas R. Donahue | 1418.0 | 0.00% |
| 2021-11-22 | 2. | 10.0 | 4.90% |
| 2021-11-22 | 2. | 10.0 | 4.70% |
| 2021-11-22 | 2. | 10.0 | 0.30% |
| 2021-11-22 | 2. | 10.0 | 0.30% |
| 2021-11-22 | 2. | 10.0 | 4.70% |
| 2021-11-22 | 2. | 10.0 | 4.90% |
| 2021-11-22 | 2. | 10.0 | 0.30% |
| 2021-11-22 | 2. | 10.0 | 4.70% |
| 2021-11-22 | 2. | 10.0 | 0.30% |
| 2021-11-22 | 2. | 10.0 | 0.30% |
| 2021-11-22 | 2. | 10.0 | 4.70% |
| 2021-11-22 | 2. | 10.0 | 4.70% |
| 2021-11-22 | 2. | 10.0 | 4.70% |
| 2021-11-22 | 2. | 10.0 | 0.30% |
| 2021-07-12 | (1) BlackRock, Inc. | 2.8M | 3.80% |
| 2021-07-08 | Biotechnology Value Fund, L.P. | 3.97M | 5.40% |
| 2021-02-16 | Cubist Systematic Strategies, LLC | 34364.0 | 4.00% |
| 2021-02-16 | Steven A. Cohen | 1.73M | 4.00% |
| 2021-02-16 | Point72 Asset Management, L.P. | 1.7M | 4.00% |
| 2021-02-16 | Point72 Hong Kong Limited | - | 4.00% |
| 2021-02-16 | Point72 Capital Advisors, Inc. | 1.7M | 4.00% |
| 2021-02-12 | J. Christopher Donahue | 7.44M | 10.55% |
| 2021-02-12 | Voting Shares Irrevocable Trust | 7.44M | 10.55% |
| 2021-02-12 | Federated Hermes, Inc. | 7.44M | 10.55% |
| 2021-02-12 | Thomas R. Donahue | 7.44M | 10.55% |
| 2021-02-12 | Rhodora J. Donahue | 7.44M | 10.55% |
| 2021-02-11 | BVF Inc. | 4.36M | 6.20% |
| 2021-02-11 | BVF Partners L.P. | 4.36M | 6.20% |
| 2021-02-11 | BVF GP HOLDINGS LLC | 4M | 5.70% |
| 2021-02-11 | BVF Partners OS Ltd. | 280.13K | 1.00% |
| 2021-02-11 | Biotechnology Value Trading Fund OS LP | 280.13K | 1.00% |
| 2021-02-11 | Biotechnology Value Fund, L.P. | 2.31M | 3.30% |
| 2021-02-11 | BVF II GP LLC | 1.69M | 2.40% |
| 2021-02-11 | BVF I GP LLC | 2.31M | 3.30% |
| 2021-02-11 | Biotechnology Value Fund II, L.P. | 1.69M | 2.40% |
| 2021-02-11 | Mark N. Lampert | 4.36M | 6.20% |
| 2021-02-10 | The Vanguard Group - 23-1945930 | 3.67M | 5.21% |
| 2021-02-10 | The Vanguard Group - 23-1945930 | 3.67M | 5.21% |
| 2021-01-29 | (1) BlackRock, Inc. | 5.67M | 8.00% |
| 2021-01-25 | Adage Capital Partners, L.P. | 4M | 5.67% |
| 2021-01-25 | Robert Atchinson | 4M | 5.67% |
| 2021-01-25 | Adage Capital Advisors, L.L.C. | 4M | 5.67% |
| 2021-01-25 | Adage Capital Partners, L.P. | 4M | 5.67% |
| 2021-01-25 | Adage Capital Partners GP, L.L.C. | 4M | 5.67% |
| 2021-01-25 | Phillip Gross | 4M | 5.67% |
| 2021-01-25 | Adage Capital Partners GP, L.L.C. | 4M | 5.67% |
| 2021-01-25 | Robert Atchinson | 4M | 5.67% |
| 2021-01-25 | Phillip Gross | 4M | 5.67% |
| 2021-01-25 | Adage Capital Advisors, L.L.C. | 4M | 5.67% |
| 2020-03-13 | Point72 Asset Management, L.P. | 3.22M | 4.00% |
| 2020-03-13 | Cubist Systematic Strategies, LLC | 20885.0 | 4.00% |
| 2020-03-13 | Point72 Hong Kong Limited | 1861.0 | 4.00% |
| 2020-03-13 | Steven A. Cohen | 3.24M | 4.00% |
| 2020-03-13 | Point72 Capital Advisors, Inc. | 3.22M | 4.00% |
| 2020-03-13 | Point72 Asset Management, L.P. | 3.22M | 4.00% |
| 2020-02-14 | Thomas R. Donahue | 6.93M | 12.90% |
| 2020-02-14 | Federated Hermes, Inc. | 6.93M | 12.90% |
| 2020-02-14 | J. Christopher Donahue | 6.93M | 12.90% |
| 2020-02-14 | Voting Shares Irrevocable Trust | 6.93M | 12.90% |
| 2020-02-14 | Rhodora J. Donahue | 6.93M | 12.90% |
| 2020-01-10 | PRIMECAP Management Company 95-3868081 | 9.49M | 15.00% |
| 2020-01-10 | PRIMECAP Management Company 95-3868081 | 9.49M | 15.00% |
| 2019-11-08 | Wellington Group Holdings LLP | 581.27K | 1.08% |
| 2019-11-08 | Wellington Management Group LLP | 581.27K | 1.08% |
| 2019-11-08 | Wellington Investment Advisors Holdings LLP | 581.27K | 1.08% |
| 2019-06-25 | Biotechnology Value Fund II, L.P. | 2.76M | 5.40% |
| 2019-06-25 | Mark N. Lampert | 6.75M | 13.10% |
| 2019-06-25 | BVF Partners OS Ltd. | 473.01K | 1.00% |
| 2019-06-25 | Biotechnology Value Trading Fund OS LP | 473.01K | 1.00% |
| 2019-06-25 | BVF Inc. | 6.75M | 13.10% |
| 2019-06-25 | Biotechnology Value Fund, L.P. | 3.29M | 6.40% |
| 2019-06-25 | BVF Partners L.P. | 6.75M | 13.10% |
| 2019-02-12 | Wellington Management Company LLP | 3.48M | 9.12% |
| 2019-02-12 | Wellington Management Group LLP | 3.71M | 9.73% |
| 2019-02-12 | Wellington Investment Advisors Holdings LLP | 3.71M | 9.73% |
| 2019-02-12 | Wellington Group Holdings LLP | 3.71M | 9.73% |
| 2019-02-04 | (1) BlackRock, Inc. | 3.05M | 8.00% |
| 2018-09-04 | Mark N. Lampert | 2.02M | 5.60% |
| 2018-09-04 | BVF Inc. | 2.02M | 5.60% |
| 2018-09-04 | BVF Partners L.P. | 2.02M | 5.60% |
| 2018-09-04 | BVF Partners OS Ltd. | 143.65K | 1.00% |
| 2018-09-04 | Biotechnology Value Fund II, L.P. | 724.24K | 2.00% |
| 2018-09-04 | Biotechnology Value Fund, L.P. | 970.4K | 2.70% |
| 2018-09-04 | BVF Partners OS Ltd. | 143.65K | 1.00% |
| 2018-09-04 | Biotechnology Value Fund II, L.P. | 724.24K | 2.00% |
| 2018-09-04 | BVF Partners L.P. | 2.02M | 5.60% |
| 2018-09-04 | Biotechnology Value Trading Fund OS LP | 143.65K | 1.00% |
| 2018-09-04 | BVF Inc. | 2.02M | 5.60% |
| 2018-09-04 | Biotechnology Value Fund, L.P. | 970.4K | 2.70% |
| 2018-09-04 | Mark N. Lampert | 2.02M | 5.60% |
| 2018-09-04 | Biotechnology Value Trading Fund OS LP | 143.65K | 1.00% |
| 2018-02-14 | IX GP”) | - | 0.00% |
| 2018-02-14 | Ralph E. Christoffersen (“Christoffersen”) | - | 0.00% |
| 2018-02-14 | Jason Lettmann (“Lettmann”) | - | 0.00% |
| 2018-02-14 | Gary R. Little (“Little”) | - | 0.00% |
| 2018-02-14 | Rebecca Lynn (“Lynn”) | - | 0.00% |
| 2018-02-14 | Gary J. Morgenthaler (“Morgenthaler”) | - | 0.00% |
| 2018-02-14 | Robert D. Pavey (“Pavey”) | - | 0.00% |
| 2018-02-14 | Henry Plain (“Plain”) | - | 0.00% |
| 2018-02-14 | Robert C. Bellas, Jr. (“Bellas”) | - | 0.00% |
| 2018-02-14 | IX”) | - | 0.00% |
| 2018-02-01 | (1) BlackRock, Inc. | 2.89M | 8.10% |
| 2017-09-28 | Robert Atchinson | 3.45M | 9.72% |
| 2017-09-28 | Adage Capital Advisors, L.L.C. | 3.45M | 9.72% |
| 2017-09-28 | Adage Capital Partners, L.P. | 3.45M | 9.72% |
| 2017-09-28 | Phillip Gross | 3.45M | 9.72% |
| 2017-09-28 | Adage Capital Partners GP, L.L.C. | 3.45M | 9.72% |
| 2017-03-10 | Wellington Investment Advisors Holdings LLP | 3.05M | 14.00% |
| 2017-03-10 | Wellington Management Group LLP | 3.05M | 14.00% |
| 2017-03-10 | Wellington Management Company LLP | 2.95M | 13.53% |
| 2017-03-10 | Wellington Group Holdings LLP | 3.05M | 14.00% |
| 2017-03-10 | Wellington Management Group LLP | 3.05M | 14.00% |
| 2017-03-06 | Hawkes Bay Master Investors (Cayman) L.P. | 1.09M | 5.28% |
| 2017-02-21 | David C. Ott | 1.61M | 7.80% |
| 2017-02-21 | Viking Global Investors LP | 1.61M | 7.80% |
| 2017-02-21 | O. Andreas Halvorsen | 1.61M | 7.80% |
| 2017-02-21 | VGE III Portfolio Ltd. | 730.88K | 3.50% |
| 2017-02-21 | Viking Global Investors LP | 1.61M | 7.80% |
| 2017-02-21 | Viking Global Performance LLC | 1.14M | 5.50% |
| 2017-02-21 | Viking Global Equities II LP | 22840.0 | 0.10% |
| 2017-02-21 | Viking Long Fund Master Ltd. | 465.94K | 2.20% |
| 2017-02-21 | Viking Global Equities LP | 388.28K | 1.90% |
| 2017-02-21 | Daniel S. Sundheim | 1.61M | 7.80% |
| 2017-02-21 | David C. Ott | 1.61M | 7.80% |
| 2017-02-21 | Viking Long Fund GP LLC | 465.94K | 2.20% |
| 2017-02-21 | VGE III Portfolio Ltd. | 730.88K | 3.50% |
| 2017-02-21 | Viking Global Equities II LP | 22840.0 | 0.10% |
| 2017-02-21 | Viking Global Performance LLC | 1.14M | 5.50% |
| 2017-02-21 | Daniel S. Sundheim | 1.61M | 7.80% |
| 2017-02-21 | O. Andreas Halvorsen | 1.61M | 7.80% |
| 2017-02-21 | Viking Long Fund Master Ltd. | 465.94K | 2.20% |
| 2017-02-21 | Viking Long Fund GP LLC | 465.94K | 2.20% |
| 2017-02-21 | Viking Global Equities LP | 388.28K | 1.90% |
| 2017-02-09 | Adage Capital Advisors, L.L.C. | 3.64M | 17.53% |
| 2017-02-09 | Robert Atchinson | 3.64M | 17.53% |
| 2017-02-09 | Adage Capital Partners GP, L.L.C. | 3.64M | 17.53% |
| 2017-02-09 | Adage Capital Partners, L.P. | 3.64M | 17.53% |
| 2017-02-09 | Phillip Gross | 3.64M | 17.53% |
| 2017-01-31 | Incyte Corporation | 1.72M | 7.40% |
| 2015-02-17 | Morgenthaler Venture Partners IX, L.P. (“Morgenthaler IX”) | 2.16M | 12.10% |
| 2015-02-17 | Morgenthaler Venture Partners IX, L.P. (“Morgenthaler IX”) | 2.16M | 12.10% |
| 2014-11-10 | Abigail P. Johnson | 2.14M | 11.98% |
| 2014-11-10 | FMR LLC | 2.14M | 11.98% |
| 2014-11-10 | Select Biotechnology Portfolio | 1.38M | 7.71% |
| 2014-11-10 | Select Biotechnology Portfolio | 1.38M | 7.71% |
| 2014-11-10 | Edward C. Johnson 3d | 2.14M | 11.98% |
| 2014-11-10 | Abigail P. Johnson | 2.14M | 11.98% |
| 2014-11-10 | FMR LLC | 2.14M | 11.98% |
| 2014-11-10 | Edward C. Johnson 3d | 2.14M | 11.98% |
| 2014-10-22 | Adage Capital Partners, L.P. | 2.77M | 15.47% |
| 2014-10-22 | Phillip Gross | 2.77M | 15.47% |
| 2014-10-22 | Adage Capital Advisors, L.L.C. | 2.77M | 15.47% |
| 2014-10-22 | Adage Capital Partners GP, L.L.C. | 2.77M | 15.47% |
| 2014-10-22 | Robert Atchinson | 2.77M | 15.47% |
| 2014-10-22 | Phillip Gross | 2.77M | 15.47% |
| 2014-10-22 | Robert Atchinson | 2.77M | 15.47% |
| 2014-10-22 | Adage Capital Partners GP, L.L.C. | 2.77M | 15.47% |
| 2014-10-22 | Adage Capital Advisors, L.L.C. | 2.77M | 15.47% |
| 2014-10-22 | Adage Capital Partners, L.P. | 2.77M | 15.47% |
| Date | Stock Price | Shares Outstanding | Market Cap | Cash & Equivalents | Total Debt | Enterprise Value |
|---|---|---|---|---|---|---|
| 2022-12-31 | $3.26 | 4.99M | $16.27M | $25.45M | $1.67M | -$7.51M |
| 2021-12-31 | $13.30 | 3.69M | $49.13M | $59.54M | $3.04M | -$7.37M |
| 2020-12-31 | $98.20 | 3.44M | $337.91M | $107.15M | $6.72M | $237.48M |
| 2019-12-31 | $114.20 | 2.37M | $270.15M | $60.44M | $8.2M | $217.91M |
| 2018-12-31 | $80.20 | 1.83M | $146.78M | $51.06M | -$ | $95.72M |
| 2017-12-31 | $167.00 | 1.65M | $275.14M | $48.48M | -$ | $226.67M |
| 2016-12-31 | $65.00 | 974.3K | $63.33M | $10.6M | -$ | $52.73M |
| 2015-12-31 | $153.20 | 902.25K | $138.22M | $6.1M | -$ | $132.12M |
| 2014-12-31 | $404.00 | 232.6K | $93.97M | $101.97M | -$ | -$8M |
| 2013-12-31 | $188.20 | 394.69K | $74.28M | $33.82M | -$ | $40.46M |
| Date | Stock Price | Shares Outstanding | Market Cap | Cash & Equivalents | Total Debt | Enterprise Value |
|---|---|---|---|---|---|---|
| 2022-12-31 | $3.26 | 4.87M | $15.87M | $25.45M | $1.67M | -$7.92M |
| 2022-09-30 | $2.94 | 4.86M | $14.3M | $34.07M | $2.02M | -$17.74M |
| 2022-06-30 | $2.46 | 5.7M | $14.02M | $41.79M | $2.37M | -$25.4M |
| 2022-03-31 | $8.08 | 3.92M | $31.7M | $44.66M | $2.71M | -$10.26M |
| 2021-12-31 | $13.30 | 3.75M | $49.89M | $59.54M | $3.04M | -$6.61M |
| 2021-09-30 | $43.60 | 3.71M | $161.58M | $84.49M | $3.36M | $80.45M |
| 2021-06-30 | $41.80 | 3.7M | $154.79M | $92.2M | $3.67M | $66.25M |
| 2021-03-31 | $48.40 | 3.61M | $174.84M | $101.35M | $3.75M | $77.23M |
| 2020-12-31 | $98.20 | 3.53M | $346.59M | $107.15M | $6.72M | $246.16M |
| 2020-09-30 | $69.00 | 3.53M | $243.43M | $120.58M | $7.15M | $130M |
| 2020-06-30 | $105.60 | 3.48M | $367.04M | $114.9M | $7.38M | $259.53M |
| 2020-03-31 | $88.80 | 3.23M | $286.63M | $40.47M | $7.79M | $253.95M |