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Spyre Therapeutics, Inc.

NASDAQ:SYRE

$102.07 USD

$3.12 (3.15%)

Volume
1.52M
Average Volume
1.39M
Market Capitalization
$6.17B
P/E Ratio
-46.82
Dividend Yield
0.00%
Price Target
$100.00
Year High
$105.09
Year Low
$14.51
Day High
Day Low
Payout Ratio
$0.00
Current Ratio
$8.97

SYRE Financial

date 2025-12-31 2024-12-31 2023-12-31 2022-12-31 2021-12-31 2020-12-31 2019-12-31 2018-12-31 2017-12-31 2016-12-31
revenue - - 886K 2.33M 18.74M - - 3.89M 5.2M 4.63M
costOfRevenue 171.65M - - - - 1.62M 901K - - -
grossProfit -171.65M - 886K 2.33M 18.74M -1.62M -901K - - -
researchAndDevelopmentExpenses 171.65M 162.79M 89.5M 58.58M 57.07M 59.64M 64.6M 36.72M 22.82M 18.14M
generalAndAdministrativeExpenses 47.91M 45.78M 39.95M 28.53M 27.32M - - - - -
sellingAndMarketingExpenses - - - - - - - - - -
sellingGeneralAndAdministrativeExpenses 47.91M 45.78M 39.95M 28.53M 27.32M 20.22M 14.83M 12.63M 10.07M 8.39M
otherExpenses -181.65M - 113.74M - - - - - - -
operatingExpenses 37.91M 208.57M 243.19M 87.11M 84.39M 79.86M 79.43M 49.35M 32.88M 26.53M
costAndExpenses 209.56M 208.57M 243.19M 87.11M 84.39M 81.48M 80.33M 49.35M 32.88M 26.53M
netInterestIncome 24.88M 21.31M 6.15M 837K 111K 593K 2.14M 1.17M 482K 244K
interestIncome 24.88M 21.31M 6.15M 837K 111K 593K 2.14M 1.17M 482K 244K
interestExpense - - - - - - - - - -
depreciationAndAmortization 10M - 964K 1.96M 1.58M 1.62M 901K 293K 249K 132K
ebitda -209.56M -207.97M -127.6M -81.99M -64.08M -79.27M -77.35M -45.17M -27.43M -21.77M
ebit -219.56M -207.97M -128.56M -83.95M -65.66M -80.89M -78.25M -45.46M -27.68M -21.91M
nonOperatingIncomeExcludingInterest 10M -599K -113.74M -830K 11000 -588K -2.08M - - -
operatingIncome -209.56M -208.57M -242.3M -84.78M -65.65M -81.48M -80.33M -45.46M -27.68M -21.91M
totalOtherIncomeExpensesNet 54.34M 599K -96.51M 830K -11000 588K 2.08M 1.12M 440K 208K
incomeBeforeTax -155.22M -207.97M -338.82M -83.95M -65.66M -80.89M -78.25M -44.35M -27.24M -21.7M
incomeTaxExpense -15000 51000 -26000 -136K 141K - - - - -
netIncomeFromContinuingOperations -155.2M -208.02M -338.79M -83.82M -65.8M -80.89M -78.25M -44.35M -27.24M -21.7M
netIncomeFromDiscontinuedOperations - - - - - - - - - -
otherAdjustmentsToNetIncome - - - - - - - - - -
netIncome -155.2M -208.02M -338.79M -83.82M -65.8M -80.89M -78.25M -44.35M -27.24M -21.7M
netIncomeDeductions -28.66M -116.93M -487.81M - - - - - - -
bottomLineNetIncome -126.54M -149.56M -94.88M -83.82M -65.8M -80.89M -78.25M -44.35M -27.24M -21.7M
eps -1.98 -3.18 -46.15 -24.86 -25.02 -37.89 -61.23 -53.25 -45.01 -55.4
date 2025-12-31 2024-12-31 2023-12-31 2022-12-31 2021-12-31 2020-12-31 2019-12-31 2018-12-31 2017-12-31 2016-12-31
cashAndCashEquivalents 85.72M 89.42M 188.89M 34.86M 15.14M 90.1M 19.25M 22.46M 12.82M 47.75M
shortTermInvestments 670.81M 513.66M 150.38M 20.85M 77.99M 56.18M 52.7M 52.05M 37.48M 15.75M
cashAndShortTermInvestments 756.53M 603.09M 339.28M 55.71M 93.13M 146.27M 71.95M 74.51M 50.3M 63.5M
netReceivables - - - 375K 815K - - - 3.08M 1.22M
accountsReceivables - - - - - - - - 3.08M 1.22M
otherReceivables - - - 375K 815K - - - - -
inventory - - - - - - - - - -
prepaids - - - - 4.95M 3.52M 2.56M 2.16M 1.61M 1.71M
otherCurrentAssets 21.25M 5.39M 2.25M 6.17M - - - - - -
totalCurrentAssets 777.78M 608.47M 341.53M 62.26M 98.89M 149.79M 74.5M 76.67M 54.99M 66.42M
propertyPlantEquipmentNet - - - 6.65M 8.36M 9.87M 7.11M 1.02M 854K 599K
goodwill - - - - - - - - - -
intangibleAssets - - - - - - - - - -
goodwillAndIntangibleAssets - - - - - - - - - -
longTermInvestments - - - - - - - - - -
taxAssets - - - - - - - - - -
otherNonCurrentAssets - 10000 331K 2.24M 2.68M 1.96M 1.57M 50000 232K 40000
totalNonCurrentAssets - 10000 331K 8.89M 11.04M 11.83M 8.68M 1.07M 1.09M 639K
otherAssets - - - - - - - - - -
totalAssets 777.78M 608.48M 341.86M 71.14M 109.93M 161.62M 83.18M 77.74M 56.08M 67.06M
totalPayables 8.92M 1.27M 17.48M 677K 3.32M 2.25M 3.15M 663K 389K 168K
accountPayables 8.9M 666K 896K 677K 3.32M 2.25M 3.15M 663K 389K 168K
otherPayables 14000 603K 16.58M - - - - - - -
accruedExpenses 18.83M 21.52M 8.57M 7.92M 9.04M 9.69M 11.11M 6.8M 1.84M 2.23M
shortTermDebt - - - - - - - - - -
capitalLeaseObligationsCurrent - - - 625K 436K 319K 351K - - -
taxPayables - - - - - - - - - -
deferredRevenue - - - 517K 2.36M - - - 20000 71000
otherCurrentLiabilities 30.94M 31.27M 5.93M 4.92M 4.99M 4.18M 3.74M 2.78M 3.38M 1.5M
totalCurrentLiabilities 58.68M 54.06M 31.98M 14.66M 20.14M 16.44M 18.36M 10.24M 5.63M 3.96M
longTermDebt - - - - - - - - - -
capitalLeaseObligationsNonCurrent - - - 4M 4.62M 5.13M 4.71M - - -
deferredRevenueNonCurrent - - - 2.18M 1.22M - - - - -
deferredTaxLiabilitiesNonCurrent - - - - - - - - - -
otherNonCurrentLiabilities 3.86M 36.62M 125.86M - - 214K 31000 72000 111K 132K
totalNonCurrentLiabilities 3.86M 36.62M 125.86M 6.18M 5.84M 5.34M 4.74M 72000 111K 132K
otherLiabilities - - - - - - - - - -
capitalLeaseObligations - - - 4.63M 5.06M 5.45M 5.06M - - -
totalLiabilities 62.54M 90.68M 157.84M 20.84M 25.98M 21.79M 23.1M 10.31M 5.74M 4.1M
treasuryStock - - - - - - - - - -
preferredStock 155.82M 155.82M 184.93M - - - - - - -
commonStock 15000 13000 10000 6000 5000 5000 3000 2000 2000 1000
retainedEarnings -1.13B -972.43M -764.41M -425.62M -341.81M -276.01M -195.12M -116.86M -72.51M -45.28M
additionalPaidInCapital 1.69B 1.33B 763.19M 475.97M 425.76M 415.82M 255.14M 184.31M 122.95M 108.25M
date 2025-12-31 2024-12-31 2023-12-31 2022-12-31 2021-12-31 2020-12-31 2019-12-31 2018-12-31 2017-12-31 2016-12-31
netIncome -155.2M -208.02M -338.79M -83.82M -65.8M -80.89M -78.25M -44.35M -27.24M -21.7M
depreciationAndAmortization -8.09M - 744K 1.57M 1.58M 996K 901K 293K 249K 132K
deferredIncomeTax - - - -327K - -213K - - - -
stockBasedCompensation 37.61M 44.83M 25.68M 7.11M 8.04M 6.26M - - - -
changeInWorkingCapital -5.93M -4.53M -5.21M -5.5M 1.83M -2.54M 7.1M 7.2M -198K 1.45M
accountsReceivables - - 375K 440K -815K - - 3.08M -1.86M 482K
inventory - - - -440K - - - - - -
accountsPayables 8.24M -230K 218K -2.64M 1.06M -544K 2.58M 239K 164K -8000
otherWorkingCapital -14.17M -4.3M -5.8M -2.86M 1.58M -2M 4.52M 3.88M 1.5M 976K
otherNonCashItems -37.64M 10.31M 217.67M 823K 638K 619K 3.78M 1.93M 4.77M 1.07M
netCashProvidedByOperatingActivities -169.25M -157.41M -99.91M -80.14M -53.72M -75.78M -65.69M -32.19M -24.62M -18.84M
investmentsInPropertyPlantAndEquipment - - - -38000 -573K -4.28M -1.49M -422K -619K -212K
acquisitionsNet - - 3.04M - - - - - - -
purchasesOfInvestments -522.21M -599.25M -166.8M -39.5M -133.08M -129M -91.93M -62.18M -64.12M -20.39M
salesMaturitiesOfInvestments 371.74M 245.97M 39.9M 96.55M 111.03M 125.68M 91.68M 47.37M 42.2M 8.45M
otherInvestingActivities 7M - 15.48M - - - - - - -
netCashProvidedByInvestingActivities -143.48M -353.28M -108.39M 57.01M -22.62M -7.6M -1.74M -15.23M -22.53M -12.16M
netDebtIssuance - - -16000 -418K -510K -20000 -25000 - - -
longTermNetDebtIssuance - - -16000 -418K -510K -20000 -25000 - - -
shortTermNetDebtIssuance - - - - - - - - - -
netStockIssuance 314.44M 405.23M 366.47M 42.87M - 153.72M 64.3M 54.05M 11.38M 49.29M
netCommonStockIssuance 314.44M 236.38M 169.11M 42.87M - 153.72M 64.3M 54.05M 11.38M 49.29M
commonStockIssuance 314.44M 236.38M 169.11M 42.87M - 153.72M 64.3M 54.05M 11.38M 49.29M
commonStockRepurchased - - - - - - - - - -
netPreferredStockIssuance - 168.85M 197.36M - - - - - - -
netDividendsPaid - - - - - - - - - -
commonDividendsPaid - - - - - - - - - -
preferredDividendsPaid - - - - - - - - - -
otherFinancingActivities -5.41M 5.67M -5.38M 222K 1.9M 816K 1.45M 3.02M 833K 76000
netCashProvidedByFinancingActivities 309.02M 410.91M 361.08M 42.68M 1.39M 154.51M 65.72M 57.07M 12.21M 49.37M
date 2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31
revenue - 90.49M - - - - - - - -
costOfRevenue - 45.25M 45.25M - - - - - - -
grossProfit - 45.25M -45.25M - - - - - - -
researchAndDevelopmentExpenses 60.41M 44.64M 45.25M 40.14M 41.62M 50.48M 44.74M 32.64M 34.93M 33.68M
generalAndAdministrativeExpenses 15.23M 12.53M 11.64M 11.79M 11.94M 10.77M 10.65M 11.51M 12.85M 14.07M
sellingAndMarketingExpenses - - - - - - - - - -
sellingGeneralAndAdministrativeExpenses 15.23M 12.53M 11.64M 11.79M 11.94M 10.77M 10.65M 11.51M 12.85M 14.07M
otherExpenses -30M 45.25M -45.25M -10M - - - - - -1.84M
operatingExpenses 45.64M 102.42M 11.64M 41.94M 53.57M 61.25M 55.39M 44.15M 47.77M 45.91M
costAndExpenses 45.64M 147.67M 56.89M 41.94M 53.57M 61.25M 55.39M 44.15M 47.77M 45.91M
netInterestIncome 7M 7.14M 5.38M 5.87M 6.49M 5.78M 5.18M 5.92M 4.43M 4.13M
interestIncome 7M 7.14M 5.38M 5.87M 6.49M 5.78M 5.18M 5.92M 4.43M 4.13M
interestExpense - - - - - - - - - -
depreciationAndAmortization - - - - - - - - - -220K
ebitda -75.64M -62.53M -11.18M -51.94M -44.79M -56.3M -69.01M -38.84M -43.82M -47.75M
ebit -75.64M -62.53M -11.18M -51.94M -44.79M -56.3M -69.01M -38.84M -43.82M -47.75M
nonOperatingIncomeExcludingInterest 30M 5.36M -45.7M 10M -8.78M -4.96M 13.62M -5.31M -3.95M 1.84M
operatingIncome -45.64M -57.17M -56.89M -41.94M -53.57M -61.25M -55.39M -44.15M -47.77M -45.91M
totalOtherIncomeExpensesNet -23.36M -5.36M 45.7M 5.22M 8.78M 4.96M -13.62M 5.31M 3.95M -17.27M
incomeBeforeTax -69M -62.53M -11.18M -36.72M -44.79M -56.3M -69.01M -38.84M -43.82M -63.18M
incomeTaxExpense - - - - -15000 1000 18000 - 32000 -
netIncomeFromContinuingOperations -69M -62.53M -11.18M -36.72M -44.77M -56.3M -69.03M -38.84M -43.86M -63.18M
netIncomeFromDiscontinuedOperations - - - - - - - - - -
otherAdjustmentsToNetIncome - - - - - - - - - -
netIncome -69M -62.53M -11.18M -36.72M -44.77M -56.3M -69.03M -38.84M -43.86M -63.18M
netIncomeDeductions - - - - - -58.46M - - - -
bottomLineNetIncome -69M -64.7M -9.02M -36.72M -44.77M 2.17M -69.03M -38.84M -43.86M -63.18M
eps -0.74 -0.69 -0.15 -0.6 -0.13 -0.15 -1.36 -0.86 -1.2 -2.91
date 2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31
cashAndCashEquivalents 97.18M 85.72M 64.9M 81.66M 48.49M 89.42M 71.58M 45.14M 227.55M 188.89M
shortTermInvestments 644.28M 670.81M 421.3M 444.92M 516.33M 513.66M 342.65M 380.85M 257.09M 150.38M
cashAndShortTermInvestments 741.47M 756.53M 486.2M 526.58M 564.82M 603.09M 414.23M 426M 484.64M 339.28M
netReceivables 4.6M - - - - - - - - -
accountsReceivables - - - - - - - - - -
otherReceivables 4.6M - - - - - - - - -
inventory - - - - - - - - - -
prepaids - - - - - - - - - -
otherCurrentAssets 17.89M 21.25M 18.41M 12.25M 4.95M 5.39M 6.85M 9.74M 2.63M 2.25M
totalCurrentAssets 763.95M 777.78M 504.6M 538.83M 569.77M 608.47M 421.08M 435.74M 487.27M 341.53M
propertyPlantEquipmentNet - - - - - - - - - -
goodwill - - - - - - - - - -
intangibleAssets - - - - - - - - - -
goodwillAndIntangibleAssets - - - - - - - - - -
longTermInvestments - - - - - - - 321K - -
taxAssets - - - - - - - - - -
otherNonCurrentAssets - - - - 10000 10000 10000 10000 329K 331K
totalNonCurrentAssets - - - - 10000 10000 10000 331K 329K 331K
otherAssets - - - - - - - - - -
totalAssets 763.95M 777.78M 504.6M 538.83M 569.78M 608.48M 421.09M 436.07M 487.6M 341.86M
totalPayables 5.69M 8.92M 11.43M 3.74M 6.24M 1.27M 19.65M 3.23M 18.63M 17.48M
accountPayables 5.69M 8.9M 7.46M 3.71M 3.69M 666K 5.16M 3.23M 3.11M 896K
otherPayables - 14000 3.97M 31000 2.55M 603K 14.48M - 15.53M 16.58M
accruedExpenses 5.07M 18.83M 18.52M 15.88M 19.7M 21.52M 9.19M 2.66M 19.09M 8.57M
shortTermDebt - - - - - - - - - -
capitalLeaseObligationsCurrent - - - - - - - - - -
taxPayables - - - - - - - - - -
deferredRevenue - - - - - - - - - -
otherCurrentLiabilities 74.4M 30.94M 16.32M 63.43M 44.74M 31.27M 28.71M 16.23M 5.1M 5.93M
totalCurrentLiabilities 85.16M 58.68M 46.27M 83.06M 70.68M 54.06M 57.54M 22.12M 42.82M 31.98M
longTermDebt - - - - - - - - - -
capitalLeaseObligationsNonCurrent - - - - - - - - - -
deferredRevenueNonCurrent - - - - - - - - - -
deferredTaxLiabilitiesNonCurrent - - - - - - - - - -
otherNonCurrentLiabilities 7.98M 3.86M 3.23M - 16.49M 36.62M 36.16M 39.56M 292.52M 125.86M
totalNonCurrentLiabilities 7.98M 3.86M 3.23M - 16.49M 36.62M 36.16M 39.56M 292.52M 125.86M
otherLiabilities - - - - - - - - - -
capitalLeaseObligations - - - - - - - - - -
totalLiabilities 93.14M 62.54M 49.5M 83.06M 87.17M 90.68M 93.7M 61.68M 335.33M 157.84M
treasuryStock - - - - - - - - - -
preferredStock 155.82M 155.82M 155.82M 155.82M 155.82M 155.82M 146.42M 155.82M 184.93M 184.93M
commonStock 15000 15000 13000 13000 13000 13000 12000 12000 10000 10000
retainedEarnings -1.2B -1.13B -1.07B -1.05B -1.02B -972.43M -916.14M -847.11M -808.27M -764.41M
additionalPaidInCapital 1.71B 1.69B 1.36B 1.35B 1.34B 1.33B 1.09B 1.07B 775.97M 763.19M
date 2026-03-31 2025-12-31 2025-09-30 2025-06-30 2025-03-31 2024-12-31 2024-09-30 2024-06-30 2024-03-31 2023-12-31
netIncome -69M -51.83M -11.18M -36.72M -44.77M -56.3M -69.03M -38.84M -43.86M -63.18M
depreciationAndAmortization - -8.09M - - - - - - - -220K
deferredIncomeTax - - - - - - - - - -1.71M
stockBasedCompensation - 9.81M 9.57M 9.38M 8.86M 9.22M 13.1M 8.68M 13.84M 17.27M
changeInWorkingCapital 244K -2.26M 5.94M -9.04M -568K 10.8M 10.35M -29.16M 3.47M -1.86M
accountsReceivables - - - - - - - - - 163K
inventory - - - - - - - - - -163K
accountsPayables -3.21M 1.45M 3.74M 23000 4.97M -20.48M 1.93M 6.63M -4.3M -783K
otherWorkingCapital 3.46M -3.71M 2.2M -9.06M -5.54M 31.28M 8.42M -35.79M 7.77M -1.08M
otherNonCashItems 11.22M 7.8M -41.44M -10.18M -4.51M -917K 16.16M -2.94M -1.99M 18.66M
netCashProvidedByOperatingActivities -57.54M -44.58M -37.12M -46.56M -40.99M -37.2M -29.42M -62.25M -28.54M -31.04M
investmentsInPropertyPlantAndEquipment - - - - - - - - - -
acquisitionsNet - - - - - - - - - -15.48M
purchasesOfInvestments -81.17M -341.71M -74.19M -34.87M -71.44M -233.09M -35.05M -178.39M -152.71M -54.17M
salesMaturitiesOfInvestments 107.75M 94.3M 99.19M 106.87M 71.38M 62.55M 77.79M 57.88M 47.75M 18.9M
otherInvestingActivities 30M - - 7M - - - - - 15.48M
netCashProvidedByInvestingActivities 56.58M -247.41M 25M 79M -61000 -170.54M 42.74M -120.52M -104.96M -35.27M
netDebtIssuance - - - - - - - - - -
longTermNetDebtIssuance - - - - - - - - - -
shortTermNetDebtIssuance - - - - - - - - - -
netStockIssuance 12.43M 312.88M 491K 848K -117K 224.62M 11.54M -169.34M 338.41M 169.39M
netCommonStockIssuance 12.43M 312.88M 491K 848K -117K 224.62M -157.31M -135K 169.2M 169.11M
commonStockIssuance 12.43M 312.88M 491K 848K - 224.62M -157.31M -135K 169.2M 169.11M
commonStockRepurchased - - - - -117K - - - - -
netPreferredStockIssuance - - - - - - 168.85M -169.2M 169.2M 282K
netDividendsPaid - - - - - - - - - -
commonDividendsPaid - - - - - - - - - -
preferredDividendsPaid - - - - - - - - - -
otherFinancingActivities - -69000 -5.13M -117K 242K 979K 1.24M 169.7M -166.24M -5.79M
netCashProvidedByFinancingActivities 12.43M 312.81M -4.64M 731K 125K 225.6M 12.78M 360K 172.16M 163.61M