Is Spyre Therapeutics, Inc. (SYRE) a Buy, Sell, or Hold?
Spyre Therapeutics, Inc.
NASDAQ:SYRE
$100.1424 USD
$1.19 (1.21%)
- Volume
- 610.48K
- Average Volume
- 1.42M
- Market Capitalization
- $6.05B
- P/E Ratio
- -45.94
- Dividend Yield
- 0.00%
- Price Target
- $100.00
- Year High
- $105.09
- Year Low
- $14.51
- Day High
- —
- Day Low
- —
- Payout Ratio
- $0.00
- Current Ratio
- $8.97
NUMBER OF INSIDERS BUYING (LAST 12 MONTHS)
22
NUMBER OF INSIDERS SELLING (LAST 12 MONTHS)
65
AMOUNT OF INSIDER SELLING (LAST 12 MONTHS)
$ 5.28M
SYRE Estimated and Actual Revenue by Quarter
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SYRE Insider Trading History
| Insider Name | Title | Date | Transaction | Cost | Filing Date |
|---|---|---|---|---|---|
| Burrows Scott L | officer: Chief Financial Officer | 2026-07-01 | M-Exempt | 14.5 | 2026-07-02 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-07-01 | M-Exempt | 14.5 | 2026-07-02 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-07-01 | S-Sale | 87.55 | 2026-07-02 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-07-01 | S-Sale | 88.37 | 2026-07-02 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-07-01 | M-Exempt | 27.46 | 2026-07-02 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-07-01 | M-Exempt | 27.46 | 2026-07-02 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-07-01 | S-Sale | 87.52 | 2026-07-02 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-07-01 | S-Sale | 88.34 | 2026-07-02 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-07-01 | S-Sale | 87.44 | 2026-07-02 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-07-01 | S-Sale | 88.12 | 2026-07-02 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-07-01 | S-Sale | 88.91 | 2026-07-02 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-25 | M-Exempt | 14.5 | 2026-06-26 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-25 | M-Exempt | 14.5 | 2026-06-26 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-25 | S-Sale | 87.12 | 2026-06-26 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-25 | S-Sale | 87.14 | 2026-06-26 |
| Fairmount Funds Management LLC | director | 2026-06-23 | C-Conversion | 0 | 2026-06-23 |
| Fairmount Funds Management LLC | director | 2026-06-23 | S-Sale | 85.31 | 2026-06-23 |
| Fairmount Funds Management LLC | director | 2026-06-23 | C-Conversion | 0 | 2026-06-23 |
| HENDERSON MICHAEL THOMAS | director | 2026-06-22 | S-Sale | 100 | 2026-06-23 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-06-03 | M-Exempt | 27.46 | 2026-06-03 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-06-03 | M-Exempt | 27.46 | 2026-06-03 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-06-03 | S-Sale | 75 | 2026-06-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-06-01 | S-Sale | 69.4 | 2026-06-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-06-01 | S-Sale | 70.5 | 2026-06-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-06-01 | S-Sale | 71.38 | 2026-06-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-01 | M-Exempt | 14.5 | 2026-06-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-01 | M-Exempt | 14.5 | 2026-06-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-01 | S-Sale | 69.75 | 2026-06-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-01 | S-Sale | 70.77 | 2026-06-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-06-01 | S-Sale | 72.06 | 2026-06-03 |
| Fairmount Funds Management LLC | director | 2026-05-27 | A-Award | 72.51 | 2026-05-29 |
| Albers Jeffrey W. | director | 2026-05-27 | A-Award | 72.51 | 2026-05-29 |
| HENDERSON MICHAEL THOMAS | director | 2026-05-27 | A-Award | 72.51 | 2026-05-29 |
| Stelzer Laurie | director | 2026-05-27 | A-Award | 72.51 | 2026-05-29 |
| McKenna Mark C. | director | 2026-05-27 | A-Award | 72.51 | 2026-05-29 |
| Milligan Sandra | director | 2026-05-27 | A-Award | 72.51 | 2026-05-29 |
| HENDERSON MICHAEL THOMAS | director | 2026-05-08 | S-Sale | 72.57 | 2026-05-08 |
| HENDERSON MICHAEL THOMAS | director | 2026-05-08 | S-Sale | 73.72 | 2026-05-08 |
| HENDERSON MICHAEL THOMAS | director | 2026-05-08 | S-Sale | 74.76 | 2026-05-08 |
| HENDERSON MICHAEL THOMAS | director | 2026-05-08 | S-Sale | 75.35 | 2026-05-08 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-05-01 | M-Exempt | 14.5 | 2026-05-01 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-05-01 | M-Exempt | 14.5 | 2026-05-01 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-05-01 | S-Sale | 71.37 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | M-Exempt | 27.46 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | M-Exempt | 27.46 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | S-Sale | 69.53 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | S-Sale | 70.61 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | S-Sale | 71.56 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | S-Sale | 72.94 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | S-Sale | 73.74 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | S-Sale | 74.6 | 2026-05-01 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-05-01 | S-Sale | 75.37 | 2026-05-01 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-05-01 | S-Sale | 69.54 | 2026-05-01 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-05-01 | S-Sale | 70.77 | 2026-05-01 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-05-01 | S-Sale | 71.76 | 2026-05-01 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-05-01 | S-Sale | 73.14 | 2026-05-01 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-05-01 | S-Sale | 74.23 | 2026-05-01 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-05-01 | S-Sale | 74.96 | 2026-05-01 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-04-01 | S-Sale | 49.2 | 2026-04-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-04-01 | S-Sale | 49.92 | 2026-04-03 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-04-01 | M-Exempt | 21.66 | 2026-04-03 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-04-01 | M-Exempt | 21.66 | 2026-04-03 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-04-01 | S-Sale | 50 | 2026-04-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-04-01 | M-Exempt | 14.5 | 2026-04-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-04-01 | M-Exempt | 14.5 | 2026-04-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-04-01 | S-Sale | 49.21 | 2026-04-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-04-01 | S-Sale | 49.98 | 2026-04-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-03-03 | M-Exempt | 14.5 | 2026-03-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-03-03 | M-Exempt | 14.5 | 2026-03-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-03-03 | S-Sale | 40.56 | 2026-03-03 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-03-03 | S-Sale | 41.66 | 2026-03-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-03-02 | S-Sale | 41.73 | 2026-03-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-03-02 | S-Sale | 42.49 | 2026-03-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-02-02 | S-Sale | 31.82 | 2026-02-04 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-02-02 | S-Sale | 32.87 | 2026-02-04 |
| HENDERSON MICHAEL THOMAS | director | 2026-01-21 | J-Other | 0 | 2026-01-23 |
| Burrows Scott L | officer: Chief Financial Officer | 2026-01-09 | A-Award | 30.61 | 2026-01-13 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-01-09 | A-Award | 30.61 | 2026-01-13 |
| Sloan Sheldon | officer: Chief Medical Officer | 2026-01-09 | A-Award | 30.61 | 2026-01-13 |
| King-Jones Heidy | officer: See Remarks | 2026-01-09 | A-Award | 30.61 | 2026-01-13 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-01-02 | S-Sale | 30.47 | 2026-01-06 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-01-02 | S-Sale | 31.79 | 2026-01-06 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2026-01-02 | S-Sale | 32.39 | 2026-01-06 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2025-12-01 | S-Sale | 28.73 | 2025-12-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2025-12-01 | S-Sale | 29.83 | 2025-12-03 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2025-11-03 | S-Sale | 23.13 | 2025-11-05 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2025-11-03 | S-Sale | 23.66 | 2025-11-05 |
| Burrows Scott L | officer: Chief Financial Officer | 2025-09-02 | S-Sale | 16.26 | 2025-09-03 |
| Fairmount Funds Management LLC | director | 2025-05-29 | A-Award | 15.55 | 2025-06-02 |
| Stelzer Laurie | director | 2025-05-29 | A-Award | 15.55 | 2025-06-02 |
| Milligan Sandra | director | 2025-05-29 | A-Award | 15.55 | 2025-06-02 |
| McKenna Mark C. | director | 2025-05-29 | A-Award | 15.55 | 2025-06-02 |
| HENDERSON MICHAEL THOMAS | director | 2025-05-29 | A-Award | 15.55 | 2025-06-02 |
| Albers Jeffrey W. | director | 2025-05-29 | A-Award | 15.55 | 2025-06-02 |
| Burrows Scott L | officer: Chief Financial Officer | 2025-01-15 | A-Award | 21.66 | 2025-01-17 |
| Sloan Sheldon | officer: Chief Medical Officer | 2025-01-15 | A-Award | 21.66 | 2025-01-17 |
| Turtle Cameron | director, officer: Chief Executive Officer | 2025-01-15 | A-Award | 21.66 | 2025-01-17 |
| King-Jones Heidy | officer: See Remarks | 2025-01-15 | A-Award | 21.66 | 2025-01-17 |
| HENDERSON MICHAEL THOMAS | director | 2025-01-10 | J-Other | 0 | 2025-01-14 |
| Albers Jeffrey W. | director | 2024-11-06 | S-Sale | 36.7631 | 2024-11-08 |