Is Upstream Bio, Inc. (UPB) a Buy, Sell, or Hold?
NASDAQ : UPB
Upstream Bio, Inc. — Financials
$7 USD
$0.09 (1.3%)
- Volume
- 37.8K
- Average Volume
- 593.6K
- Market Capitalization
- $380.94M
- P/E Ratio
- -2.41
- Dividend Yield
- 0.00%
- Price Target
- $20.00
- Year High
- $33.68
- Year Low
- $5.85
- Day High
- —
- Day Low
- —
- Payout Ratio
- $0.00
- Current Ratio
- $27.99
UPB Financial Statements
| date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| revenue | 2.85M | 2.37M | 2.38M | 1.21M |
| costOfRevenue | - | - | - | - |
| grossProfit | 2.85M | 2.37M | 2.38M | 1.21M |
| researchAndDevelopmentExpenses | 136.81M | 62.97M | 31.8M | 18.66M |
| generalAndAdministrativeExpenses | 26.41M | 17.17M | 10.7M | 6.46M |
| sellingAndMarketingExpenses | - | - | - | - |
| sellingGeneralAndAdministrativeExpenses | 26.41M | 17.17M | 10.7M | 6.46M |
| otherExpenses | - | - | - | - |
| operatingExpenses | 163.22M | 80.13M | 42.49M | 25.12M |
| costAndExpenses | 163.22M | 80.13M | 42.49M | 25.12M |
| netInterestIncome | 16.93M | 12.12M | 4.16M | 205K |
| interestIncome | 16.93M | 12.12M | 4.16M | 205K |
| interestExpense | - | - | - | - |
| depreciationAndAmortization | 188K | 89000 | 60000 | 7000 |
| ebitda | -143.26M | -62.72M | -20.48M | -23.86M |
| ebit | -143.44M | -62.81M | -20.54M | -23.87M |
| nonOperatingIncomeExcludingInterest | -16.92M | -14.96M | -19.58M | -41000 |
| operatingIncome | -160.36M | -77.76M | -40.11M | -23.91M |
| totalOtherIncomeExpensesNet | 16.92M | 14.96M | 19.58M | 41000 |
| incomeBeforeTax | -143.44M | -62.81M | -20.54M | -23.87M |
| incomeTaxExpense | - | - | - | - |
| netIncomeFromContinuingOperations | -143.44M | -62.81M | -20.54M | -23.87M |
| netIncomeFromDiscontinuedOperations | - | - | - | - |
| otherAdjustmentsToNetIncome | - | - | - | - |
| netIncome | -143.44M | -62.81M | -20.54M | -23.87M |
| netIncomeDeductions | - | - | - | - |
| bottomLineNetIncome | -143.44M | -76.4M | -38.26M | -23.87M |
| eps | -2.66 | -1.49 | -1.05 | -0.66 |
| date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| cashAndCashEquivalents | 101.58M | 325.89M | 25.83M | 17.05M |
| shortTermInvestments | 239.93M | 144.56M | 83.98M | - |
| cashAndShortTermInvestments | 341.51M | 470.45M | 109.81M | 17.05M |
| netReceivables | 668K | 1.18M | 236K | 412K |
| accountsReceivables | 668K | 613K | 98000 | 412K |
| otherReceivables | - | 567K | 138K | - |
| inventory | - | - | - | - |
| prepaids | - | 7.04M | 6.58M | 611K |
| otherCurrentAssets | 9.62M | 494K | 370K | 233K |
| totalCurrentAssets | 351.8M | 479.16M | 117M | 18.31M |
| propertyPlantEquipmentNet | 1.78M | 2.36M | 202K | 164K |
| goodwill | - | - | - | - |
| intangibleAssets | - | - | - | - |
| goodwillAndIntangibleAssets | - | - | - | - |
| longTermInvestments | - | - | - | - |
| taxAssets | - | - | - | - |
| otherNonCurrentAssets | 194K | 194K | -1 | 7000 |
| totalNonCurrentAssets | 1.98M | 2.56M | 202K | 171K |
| otherAssets | - | - | - | - |
| totalAssets | 353.77M | 481.72M | 117.2M | 18.48M |
| totalPayables | 2.73M | 4.04M | 1.99M | 712K |
| accountPayables | 2.73M | 4.04M | 1.99M | 712K |
| otherPayables | - | - | - | - |
| accruedExpenses | - | 3.3M | 2.31M | 3.16M |
| shortTermDebt | 720K | - | - | - |
| capitalLeaseObligationsCurrent | - | 704K | 45000 | 87000 |
| taxPayables | - | - | - | - |
| deferredRevenue | - | - | - | - |
| otherCurrentLiabilities | 10.01M | 2.7M | 2.17M | 893K |
| totalCurrentLiabilities | 13.45M | 10.74M | 6.52M | 4.86M |
| longTermDebt | 549K | - | - | - |
| capitalLeaseObligationsNonCurrent | - | 1.13M | - | 7000 |
| deferredRevenueNonCurrent | - | - | - | - |
| deferredTaxLiabilitiesNonCurrent | - | - | - | - |
| otherNonCurrentLiabilities | - | - | 233.81M | 119.77M |
| totalNonCurrentLiabilities | 549K | 1.13M | 233.81M | 119.78M |
| otherLiabilities | - | - | - | - |
| capitalLeaseObligations | - | 1.83M | 45000 | 94000 |
| totalLiabilities | 14M | 11.87M | 240.32M | 124.63M |
| treasuryStock | - | - | - | - |
| preferredStock | - | - | - | - |
| commonStock | 54000 | 53000 | 3000 | 3000 |
| retainedEarnings | -334.22M | -190.78M | -127.97M | -107.44M |
| additionalPaidInCapital | 673.41M | 660.6M | 4.82M | 1.28M |
| date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| netIncome | -143.44M | -62.81M | -20.54M | -23.87M |
| depreciationAndAmortization | -1.31M | 89000 | 60000 | 7000 |
| deferredIncomeTax | - | - | - | - |
| stockBasedCompensation | 10.33M | 6M | 3.43M | 1.28M |
| changeInWorkingCapital | 589K | 1.87M | -4.3M | 3.41M |
| accountsReceivables | -55000 | -515K | 314K | -412K |
| inventory | - | - | - | - |
| accountsPayables | -1.28M | 2.02M | 1.28M | 462K |
| otherWorkingCapital | 1.92M | 371K | -5.9M | 3.36M |
| otherNonCashItems | 561K | -4.33M | -16.57M | 149K |
| netCashProvidedByOperatingActivities | -133.28M | -59.17M | -37.93M | -19.02M |
| investmentsInPropertyPlantAndEquipment | -165K | -511K | -144K | -82000 |
| acquisitionsNet | - | - | - | - |
| purchasesOfInvestments | -385.88M | -290.61M | -128.99M | - |
| salesMaturitiesOfInvestments | 292.56M | 231.64M | 46.29M | - |
| otherInvestingActivities | - | - | - | - |
| netCashProvidedByInvestingActivities | -93.48M | -59.48M | -82.84M | -82000 |
| netDebtIssuance | - | - | - | - |
| longTermNetDebtIssuance | - | - | - | - |
| shortTermNetDebtIssuance | - | - | - | - |
| netStockIssuance | 2.44M | 422.65M | 129.43M | 10M |
| netCommonStockIssuance | 2.44M | 272.72M | - | - |
| commonStockIssuance | 2.44M | 272.72M | 129.55M | 9.96M |
| commonStockRepurchased | - | - | - | - |
| netPreferredStockIssuance | - | 149.92M | 129.43M | 10M |
| netDividendsPaid | - | - | - | - |
| commonDividendsPaid | - | - | - | - |
| preferredDividendsPaid | - | - | - | - |
| otherFinancingActivities | - | -3.74M | 118K | -37000 |
| netCashProvidedByFinancingActivities | 2.44M | 418.91M | 129.55M | 9.96M |
| date | 2026-06-30 | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|
| revenue | 773K | 1.03M | 668K | 683K | 937K | 566K | 613K | 607K | 510K | 640K |
| costOfRevenue | - | 49000 | - | - | - | - | - | - | - | - |
| grossProfit | 773K | 985K | 668K | 683K | 937K | 566K | 613K | 607K | 510K | 640K |
| researchAndDevelopmentExpenses | 36.09M | 36.56M | 40.17M | 32.98M | 37.86M | 25.8M | 21.77M | 15.43M | 14.07M | 11.69M |
| generalAndAdministrativeExpenses | 7.05M | 8.08M | 6.67M | 5.54M | 7.42M | 6.78M | 5.16M | 4.07M | 3.98M | 3.96M |
| sellingAndMarketingExpenses | - | - | - | - | - | - | - | - | - | - |
| sellingGeneralAndAdministrativeExpenses | 7.05M | 8.08M | 6.67M | 5.54M | 7.42M | 6.78M | 5.16M | 4.07M | 3.98M | 3.96M |
| otherExpenses | - | -49000 | - | - | - | - | - | - | - | - |
| operatingExpenses | 43.14M | 44.6M | 46.84M | 38.52M | 45.28M | 32.58M | 26.93M | 19.5M | 18.05M | 15.65M |
| costAndExpenses | 43.14M | 44.65M | 46.84M | 38.52M | 45.28M | 32.58M | 26.93M | 19.5M | 18.05M | 15.65M |
| netInterestIncome | 2.66M | 3.05M | 3.65M | 4.1M | 4.43M | 4.74M | 5.08M | 2.9M | 2.88M | 1.27M |
| interestIncome | 2.66M | 3.05M | 3.65M | 4.1M | 4.43M | 4.74M | 5.08M | 2.9M | 2.88M | 1.27M |
| interestExpense | - | - | - | - | - | - | - | - | - | - |
| depreciationAndAmortization | - | 49000 | 57000 | 46000 | 42000 | 43000 | 49000 | 14000 | 13000 | 13000 |
| ebitda | -39.7M | -40.54M | -42.4M | -33.7M | -39.92M | -27.23M | -21.19M | -15.98M | -14.66M | -10.88M |
| ebit | -39.7M | -40.59M | -42.46M | -33.75M | -39.97M | -27.27M | -21.24M | -15.99M | -14.68M | -10.89M |
| nonOperatingIncomeExcludingInterest | -2.67M | -3.02M | -3.71M | -4.09M | -4.38M | -4.74M | -5.08M | -2.9M | -2.86M | -4.12M |
| operatingIncome | -42.37M | -43.62M | -46.17M | -37.83M | -44.35M | -32.01M | -26.32M | -18.89M | -17.54M | -15.01M |
| totalOtherIncomeExpensesNet | 2.67M | 3.02M | 3.71M | 4.09M | 4.38M | 4.74M | 5.08M | 2.9M | 2.86M | 4.12M |
| incomeBeforeTax | -39.7M | -40.59M | -42.46M | -33.75M | -39.97M | -27.27M | -21.24M | -15.99M | -14.68M | -10.89M |
| incomeTaxExpense | - | - | - | - | - | - | - | - | - | - |
| netIncomeFromContinuingOperations | -39.7M | -40.59M | -42.46M | -33.75M | -39.97M | -27.27M | -21.24M | -15.99M | -14.68M | -10.89M |
| netIncomeFromDiscontinuedOperations | - | - | - | - | - | - | - | - | - | - |
| otherAdjustmentsToNetIncome | - | - | - | - | - | - | - | - | - | - |
| netIncome | -39.7M | -40.59M | -42.46M | -33.75M | -39.97M | -27.27M | -21.24M | -15.99M | -14.68M | -10.89M |
| netIncomeDeductions | - | - | - | - | - | - | - | - | - | - |
| bottomLineNetIncome | -39.7M | -40.59M | -42.46M | -33.75M | -39.97M | -27.27M | -21.79M | -21.03M | -19.56M | -14.01M |
| eps | -0.73 | -0.75 | -0.79 | -0.63 | -0.74 | -0.51 | -0.41 | -0.41 | -0.38 | -0.27 |
| date | 2026-06-30 | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|
| cashAndCashEquivalents | 79.4M | 96.72M | 101.58M | 72.16M | 45.46M | 71.31M | 325.89M | 32.95M | 47.34M | - |
| shortTermInvestments | 181.91M | 197.86M | 239.93M | 300.26M | 348.12M | 360.07M | 144.56M | 187.71M | 188.47M | - |
| cashAndShortTermInvestments | 261.31M | 294.58M | 341.51M | 372.43M | 393.58M | 431.38M | 470.45M | 220.66M | 235.8M | 109.81M |
| netReceivables | 2.15M | 1.03M | 668K | 683K | 2.64M | 1.74M | 1.18M | 1.09M | 907K | - |
| accountsReceivables | 772K | 1.03M | 668K | 683K | 937K | 566K | 613K | 607K | 510K | - |
| otherReceivables | 1.38M | - | - | - | 1.71M | 1.17M | 567K | 485K | 397K | - |
| inventory | - | - | - | - | - | - | - | - | - | - |
| prepaids | - | - | - | - | 21.23M | 19.67M | 7.04M | 5.13M | 5.71M | - |
| otherCurrentAssets | 16.14M | 20.67M | 9.62M | 15.91M | 818K | 1M | 494K | 388K | 610K | -109.81M |
| totalCurrentAssets | 279.6M | 316.28M | 351.8M | 389.02M | 418.27M | 453.79M | 479.16M | 227.27M | 243.03M | - |
| propertyPlantEquipmentNet | 1.38M | 1.58M | 1.78M | 1.98M | 2.06M | 2.19M | 2.36M | 2.49M | 133K | - |
| goodwill | - | - | - | - | - | - | - | - | - | - |
| intangibleAssets | - | - | - | - | - | - | - | - | - | - |
| goodwillAndIntangibleAssets | - | - | - | - | - | - | - | - | - | - |
| longTermInvestments | - | - | - | - | - | - | - | - | - | - |
| taxAssets | - | - | - | - | - | - | - | - | - | - |
| otherNonCurrentAssets | 194K | 194K | 194K | 194K | 194K | 194K | 194K | 2.94M | 1.35M | - |
| totalNonCurrentAssets | 1.57M | 1.78M | 1.98M | 2.18M | 2.25M | 2.38M | 2.56M | 5.43M | 1.48M | - |
| otherAssets | - | - | - | - | - | - | - | - | - | - |
| totalAssets | 281.17M | 318.05M | 353.77M | 391.2M | 420.52M | 456.17M | 481.72M | 232.7M | 244.51M | - |
| totalPayables | 2.31M | 1.71M | 2.73M | 3.95M | 2.55M | 4.72M | 4.04M | 4.9M | 5.56M | - |
| accountPayables | 2.31M | 1.71M | 2.73M | 3.95M | 2.55M | 4.72M | 4.04M | 4.9M | 5.56M | - |
| otherPayables | - | - | - | - | - | - | - | - | - | - |
| accruedExpenses | - | - | - | - | 5.76M | 3.27M | 3.3M | 3.18M | 3.06M | - |
| shortTermDebt | 728K | 724K | 720K | 716K | - | - | - | - | - | - |
| capitalLeaseObligationsCurrent | - | - | - | - | 712K | 708K | 704K | 678K | - | - |
| taxPayables | - | - | - | - | - | - | - | - | - | - |
| deferredRevenue | - | - | - | - | - | - | - | - | - | - |
| otherCurrentLiabilities | 6.95M | 11.24M | 10.01M | 7.24M | 1.9M | 875K | 2.7M | 2.12M | 1.62M | - |
| totalCurrentLiabilities | 9.99M | 13.67M | 13.45M | 11.91M | 10.93M | 9.57M | 10.74M | 10.87M | 10.24M | - |
| longTermDebt | 226K | 390K | 549K | 703K | - | - | - | - | - | - |
| capitalLeaseObligationsNonCurrent | - | - | - | - | 849K | 992K | 1.13M | 1.26M | - | - |
| deferredRevenueNonCurrent | - | - | - | - | - | - | - | - | - | - |
| deferredTaxLiabilitiesNonCurrent | - | - | - | - | - | - | - | - | - | - |
| otherNonCurrentLiabilities | - | - | - | - | - | - | - | 380.87M | 380.87M | -107.81M |
| totalNonCurrentLiabilities | 226K | 390K | 549K | 703K | 849K | 992K | 1.13M | 382.14M | 380.87M | -107.81M |
| otherLiabilities | - | - | - | - | - | - | - | - | - | - |
| capitalLeaseObligations | - | - | - | - | 1.56M | 1.7M | 1.83M | 1.94M | - | - |
| totalLiabilities | 10.21M | 14.06M | 14M | 12.61M | 11.78M | 10.56M | 11.87M | 393.01M | 391.12M | -107.81M |
| treasuryStock | - | - | - | - | - | - | - | - | - | - |
| preferredStock | - | - | - | - | - | - | - | - | - | 230.94M |
| commonStock | 54000 | 54000 | 54000 | 56000 | 54000 | 53000 | 53000 | 3000 | 3000 | - |
| retainedEarnings | -414.52M | -374.81M | -334.22M | -291.76M | -258.02M | -218.05M | -190.78M | -169.54M | -153.55M | - |
| additionalPaidInCapital | 685.54M | 678.66M | 673.41M | 669.8M | 666.45M | 663.24M | 660.6M | 8.87M | 6.99M | - |
| date | 2026-06-30 | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 |
|---|---|---|---|---|---|---|---|---|---|---|
| netIncome | -39.7M | -40.59M | -42.46M | -33.75M | -39.97M | -27.27M | -21.24M | -15.99M | -14.68M | -10.89M |
| depreciationAndAmortization | 50000 | -705K | 5.88M | -2.83M | 42000 | 43000 | 49000 | 14000 | 13000 | 13000 |
| deferredIncomeTax | - | - | - | - | - | - | - | - | - | - |
| stockBasedCompensation | 4.35M | 4.65M | 2.51M | 2.59M | 2.6M | 2.64M | 2.09M | 1.86M | 1.41M | 643K |
| changeInWorkingCapital | -440K | -11.35M | 7.75M | 8.88M | -1.06M | -14.97M | -1.32M | 717K | 6.34M | -3.86M |
| accountsReceivables | 262K | -366K | 15000 | 254K | -371K | 47000 | -6000 | -97000 | 228K | -640K |
| inventory | - | - | - | - | - | - | - | - | - | - |
| accountsPayables | 604K | -1.02M | -1.23M | 1.4M | -2.17M | 711K | -871K | -174K | 3.68M | -615K |
| otherWorkingCapital | -1.31M | -9.97M | 8.96M | 7.22M | 1.47M | -15.73M | -441K | 988K | 2.43M | -2.61M |
| otherNonCashItems | 117K | 151K | -4.31M | 2.86M | -847K | -1.6M | 813K | -564K | -1.12M | -3.46M |
| netCashProvidedByOperatingActivities | -35.62M | -47.85M | -30.63M | -22.24M | -39.24M | -41.16M | -19.61M | -13.96M | -8.04M | -17.56M |
| investmentsInPropertyPlantAndEquipment | - | - | -47000 | 47000 | -47000 | - | -185K | -326K | - | - |
| acquisitionsNet | - | - | - | - | - | - | - | - | - | - |
| purchasesOfInvestments | -50.94M | -14.42M | -38.28M | -24.46M | -57.08M | -266.06M | -42.21M | -73.4M | -151.59M | -23.41M |
| salesMaturitiesOfInvestments | 66.7M | 56.82M | 97.28M | 72.71M | 69.9M | 52.68M | 84.3M | 75.14M | 34.93M | 37.26M |
| otherInvestingActivities | - | - | -7000 | -111K | - | - | - | - | - | - |
| netCashProvidedByInvestingActivities | 15.76M | 42.4M | 58.94M | 48.19M | 12.77M | -213.38M | 41.91M | 1.41M | -116.65M | 13.85M |
| netDebtIssuance | - | - | - | - | - | - | - | - | - | - |
| longTermNetDebtIssuance | - | - | - | - | - | - | - | - | - | - |
| shortTermNetDebtIssuance | - | - | - | - | - | - | - | - | - | - |
| netStockIssuance | 2.53M | 598K | 1.1M | 760K | 612K | -34000 | 270.65M | 19000 | -9.28M | - |
| netCommonStockIssuance | 2.53M | 598K | 1.1M | 760K | 612K | -34000 | 270.65M | - | - | - |
| commonStockIssuance | 2.53M | 598K | 1.1M | 760K | 612K | -34000 | 270.65M | - | - | - |
| commonStockRepurchased | - | - | - | - | - | - | - | - | - | - |
| netPreferredStockIssuance | - | - | - | - | - | - | - | - | - | - |
| netDividendsPaid | - | - | - | - | - | - | - | - | - | - |
| commonDividendsPaid | - | - | - | - | - | - | - | - | - | - |
| preferredDividendsPaid | - | - | - | - | - | - | - | - | - | - |
| otherFinancingActivities | - | - | - | - | - | - | - | -1.64M | 140.52M | 9.39M |
| netCashProvidedByFinancingActivities | 2.53M | 598K | 1.1M | 760K | 612K | -34000 | 270.65M | -1.64M | 140.52M | 9.39M |